Acne vulgaris is one of the most common skin diseases. This problem affects teenagers, adults, and, increasingly, women in their thirties. Although it may sound harmless, it can make life miserable—it causes inflammation, leaves scars, and affects appearance, self-esteem, and daily functioning. In an era of growing bacterial resistance to antibiotics and the popularity of “dermoactive cosmetics,” we need new, safe, and practical solutions. Scientists from Wroclaw have developed just such promising and modern solutions.
A team of researchers from Wroclaw Medical University: Agnieszka Kostrzębska, Dr Adam Junka, PhD and Prof. Witold Musiał combined a well-known antibiotic (tetracycline) with a modern skincare ingredient, azelaic acid. They put them in a gel that spreads easily on the skin and can reach the areas where acne lesions develop.
The combination of tetracycline and azelaic acid is not accidental – each of these substances plays a different, complementary role. Tetracycline eliminates the bacteria responsible for the development of acne, while azelaic acid regulates sebum secretion, soothes inflammation, moisturizes, and supports skin regeneration. Thanks to this combination, the gel not only effectively combats acne lesions but also improves the overall skin condition without side effects such as dryness, exfoliation, or redness.
The new gel has undergone thorough testing for efficacy and safety. It has a strong effect against the bacteria responsible for acne development, effectively penetrates sebum, and reaches directly to the inflamed areas. It also inhibits the formation of biofilm – a difficult-to-remove layer of bacteria that promotes the recurrence of skin lesions. The product demonstrated no toxicity in tests, indicating that it is safe for use. In addition, the gel containing azelaic acid proved to be more stable and effective than the version without this ingredient, which means that it retains its properties for a more extended period, even when stored at home.
For now, the preparation is being tested in laboratory conditions. But the researchers already have a plan for the future:
“At this stage, we have not yet started clinical trials in patients, although we do have plans to do so. Currently, we want to focus on completing laboratory and preclinical studies, which are a necessary step before the preparation can be tested on humans,” explains Agnieszka Kostrzębska.
Advanced research is planned on human skin cell lines, biofilm models, and so-called ex vivo skin collected, for example, during surgical procedures. Researchers aim to test not only the antibacterial effectiveness but also the impact of the preparation on the epidermal barrier, skin hydration, and acne discoloration.
The innovative gel is not only an attempt to combat bacteria but also an attempt to fight them. It is also a response to the need for a comprehensive approach to skin treatment, combining therapeutic and care effects.
“We are increasingly recognizing that effective treatment of skin diseases such as acne or atopic dermatitis cannot be based solely on eliminating bacteria. The skin is a complex ecosystem — it is important to maintain the balance of the microbiota, alleviate inflammation, and support the protective functions of the epidermis,” emphasizes the researcher.
This approach can also reduce the risk of developing antibiotic resistance, thanks to lower doses and shorter treatment durations. For the patient, this means fewer side effects, greater comfort, and faster results.
The new gel may be beneficial for people with recurrent or treatment-resistant acne, sensitive or dehydrated skin, as well as for those who do not tolerate traditional ointments and tonics with acids. It is also a suitable solution for individuals seeking a product that combines therapeutic and skincare properties.
Although the product is still a long way from entering the market, Polish science shows that it may have efficient applications – straight from the laboratory to our bathrooms.
This material is based on an article: International Journal of Molecular Science; Synergy of Tetracyclines and Potassium Azeloyl Diglycinate (Azeloglycine) in Hydrogels: Evaluation of Stability, Antimicrobial Activity, and Physicochemical Properties
Authors: Agnieszka Kostrzębska, Adam Junka, Witold Musiał
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